Back row, from left to right: Stefan Stamm, Dominique Olbert, Shivendra Kishore, Kerstin Kortenbruck.
Front row, from left to right: Ilona Rafalska, Tatyana Novoyatleva, Bettina Heinrich, Natalya Benderska, Zhaiyi Zhang.
Overview:
In higher eukaryotes, genes are interupted by intervening sequences (introns). After the DNA of a gene is copied into pre-mRNA, these intronic sequences have to be removed and the remaining sequences (exons) are joined. This process is known as pre-mRNA splicing. Often, a cell can alternatively include or exclude a sequence from the mature mRNA, a process that is known as alternative splicing.
Alternative splicing is an important mechanism to create protein diversity. It allows to create more than one protein from a given pre-mRNA, or to switch off the protein by including a stop codon in its mRNA. Alternative splicing pathways are not static, but subject to changes e.g. in development, or in response to outside stimuli. Numerous examples of alternative splicing have been observed in the brain, where this mechanism might contribute to neuronal plasticity.
We are therefore interested in answering the following questions:
Current Group Members:
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Back row, from left to right: Stefan Stamm, Dominique Olbert, Shivendra Kishore, Kerstin Kortenbruck. Front row, from left to right: Ilona Rafalska, Tatyana Novoyatleva, Bettina Heinrich, Natalya Benderska, Zhaiyi Zhang. |
Previous Group Members:
Contact and Funding Information:
If you are interested in our work, contact Stefan Stamm. If you are interested in applying for a position, please send a cover letter, your CV, and three written letters of reference to Dominique Olbert.
Financial support for the group comes form:
Click here for more details on our current funding
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Mahron Stiftung |
Stanley Foundation |