G r o u p M e m b e r P u b l i c a t i o n s
Arizaca Maquera KA, Welden JR, Margvelani G, Miranda Sardón SC, Hart S, Robil N, Gonzalo Hernandez A, de la Grange P, Nelson PT, Stamm S. Alzheimer’s disease pathogenetic progression is associated with changes in regulated retained introns and editing of circular RNAs. Front Mol Neurosci. 2023; in press.
Welden JR, Margvelani G, Arizaca Maquera KA, Gudlavalleti B, Miranda Sardón SC, Campos A, Robil N, Lee DC, Gonzalo Hernandez A, Wang W, Di J, de la Grange P, Nelson PT, Stamm S. RNA editing of microtubule associated protein tau circular RNAs promotes their translation and tau tangle formation. Nucleic Acids Res. 2022 Dec 9;50(22):12979-12996
Hart SN, Patel SP, Michael FM, Stoilov P, Leow CJ, Hernandez AG, Jolly A, de la Grange P, Rabchevsky AG, Stamm S. Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns. Neurotrauma Rep. 2022;3(1):105-21. Epub 2022/04/12. doi: 10.1089/neur.2021.0042. PubMed PMID: 35403103; PMCID: PMC8985541.
Tubero Euzebio Alves V, Al-Attar A, Alimova Y, Maynard MH, Kirakodu S, Martinez-Porras A, Hawk GS, Ebersole JL, Stamm S, Gonzalez OA. Streptococcus gordonii-Induced miRNAs Regulate CCL20 Responses in Human Oral Epithelial Cells. Infect Immun. 2022;90(3):e0058621. Epub 2022/02/01. doi: 10.1128/iai.00586-21. PubMed PMID: 35099275; PMCID: PMC8929334.
Welden, J.R., Pawluchin, A., van Doorn, J., Stamm, S. Use of Alu Element Containing Minigenes to Analyze Circular RNAs. J. Vis. Exp.(157), e59760, doi:10.3791/59760 (2020).
Welden JR, Stamm S. Pre-mRNA structures forming circular RNAs. Biochim Biophys Acta Gene Regul Mech. 2019 Nov - Dec;1862(11-12):194410.
Stamm S, Lodmell JS. C/D box snoRNAs in viral infections: RNA viruses use old dogs for new tricks. Noncoding RNA Res. 2019;4(2):46-53.
Welden JR, Zhang Z, Duncan MJ, Falaleeva M, Wells T, Stamm S. The posterior pituitary expresses the serotonin receptor 2C. Neurosci Lett. 2018;684:132-9.
Welden JR, van Doorn J, Nelson PT, Stamm S. The human MAPT locus generates circular RNAs. Biochim Biophys Acta Mol Basis Dis. 2018;1864(9 Pt B):2753-60.
Falaleeva M, Welden JR, Duncan MJ, Stamm S. C/D-box snoRNAs form methylating and non-methylating ribonucleoprotein complexes: Old dogs show new tricks. Bioessays. 2017;39(6).
Thurman M, van Doorn J, Danzer B, Webb TR, Stamm S. Changes in Alternative Splicing as Pharmacodynamic Markers for Sudemycin D6. Biomark Insights. 2017;12:1177271917730557.
Stamm S, Gruber SB, Rabchevsky AG, Emeson RB. The activity of the serotonin receptor 2C is regulated by alternative splicing. Hum Genet. 2017.
Webb TR, Stamm S. Targeting Pre-mRNA Processing in Cancer. Comprehensive Medicinal Chemistry, 3rd Edition. 2017.
Stamm S. Alternative splicing and human disease. Enzcyclopedia of Life Sciences. 2017.
Falaleeva M, Pages A, Matuszek Z, Hidmi S, Agranat-Tamir L, Korotkov K, Nevo Y, Eyras E, Sperling R, Stamm S. Dual function of C/D box snoRNAs in rRNA modification and alternative pre-mRNA splicing Proc Natl Acad Sci U S A. 2016;113(12):E1625-34.PubMed PMID: 26957605.
Zhang Z, Shen M, Gresch P, Ghamari-Langroudi M, Rabchevsky AG, Emeson RB, Stamm S. Oligonucleotide-induced alternative splicing of serotonin 2C receptor reduces food intake. EMBO molecular medicine. 2016;8(8):878-94.PubMed PMID: 27406820.
Matveeva E, Maiorano J, Zhang Q, Eteleeb AM, Convertini P, Chen J, Infantino V, Stamm S, Wang J, Rouchka EC, Fondufe-Mittendorf YN. Involvement of PARP1 in the regulation of alternative splicing. Cell discovery. 2016;2:15046. PubMed PMID: 27462443.
Kwiatkowski S, Sviripa VM, Zhang Z, Wendlandt AE, Hobartner C, Watt DS, Stamm S. Synthesis of a norcantharidin-tethered guanosine: Protein phosphatase-1 inhibitors that change alternative splicing. Bioorganic & medicinal chemistry letters. 2016;26(3):965-8.PubMed PMID: 26725024
Falaleeva, M., Surface, J., Shen, M., de la Grange, P. and Stamm, S. SNORD116 and SNORD115 change expression of multiple genes and modify each other's activity. Gene (2015).
Shi Y, Joyner AS, Shadrick W, Palacios G, Lagisetti C, Potter PM, Sambucetti LC, Stamm S, Webb TR. Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates. Pharmacology research & perspectives. 2015;3(4):e00158.PubMed PMID: 26171237.
Jamros, M.A., Aubol, B.E., Keshwani, M.M., Zhang, Z., Stamm, S. and Adams, J.A. Intra-domain cross talk regulates serine-arginine protein kinase 1 dependent phosphorylation and splicing function of transformer 2 beta 1. J. Biol. Chem. (2015).
Shen M, Falaleeva M, Korotkova N, & Stamm S (2015) Direct cloning of double-stranded RNAs. Methods in Molecular Biology 1296:53-64. PMID: 25791590
Convertini P, Shen M, Potter PM, Palacios G, Lagisetti C, de la Grange P, Horbinski C, Fondufe-Mittendorf YN, Webb TR, Stamm S. Sudemycin E influences alternative splicing and changes chromatin modifications. Nucleic Acids Res. 2014 Apr;42(8):4947-61. doi: 10.1093/nar/gku151. Epub 2014 Mar 11.
PMID: 24623796
Zhang Z, Convertini P, Shen M, Xu X, Lemoine F, de la Grange P, Andres DA, Stamm S. Valproic acid causes proteasomal degradation of DICER and influences miRNA expression. PLoS One. 2013 Dec 17;8(12):e82895. doi: 10.1371/journal.pone.0082895. eCollection 2013.
PMID: 24358235
Hirschfeld M, Zhang B, Jaeger M, Stamm S, Erbes T, Mayer S, Tong X, Stickeler E. Hypoxia-dependent mRNA expression pattern of splicing factor YT521 and its impact on oncological important target gene expression. Mol Carcinog. 2013 Jun 13. doi: 10.1002/mc.22045.
PMID: 23765422
Falaleeva M, Sulsona CR, Zielke HR, Currey KM, de la Grange P, Aslanzadeh V, Driscoll DJ, Stamm S. Molecular characterization of a patient presumed to have prader-willi syndrome. Clin Med Insights Case Rep. 2013 May 5;6:79-86. doi: 10.4137/CCRep.S11510. Print 2013.
PMID: 23700380
Convertini P, Zhang J, de la Grange P, Hayward LJ, Zhu H, Stamm S. Genome wide array analysis indicates that an amyotrophic lateral sclerosis mutation of FUS causes an early increase of CAMK2N2 in vitro. Biochim Biophys Acta. 2013 Aug;1832(8):1129-35. doi: 10.1016/j.bbadis.2013.03.015. Epub 2013 Mar 29.
PMID: 23545117
Zhang Z, Falaleeva M, Agranat-Tamir L, Pages A, Eyras E, Sperling J, Sperling R, Stamm S. The 5' untranslated region of the serotonin receptor 2C pre-mRNA generates miRNAs and is expressed in non-neuronal cells. Exp Brain Res. 2013 Oct;230(4):387-94. doi: 10.1007/s00221-013-3458-8. Epub 2013 Mar 15.
PMID: 23494383
Shen M, Bellaousov S, Hiller M, de La Grange P, Creamer TP, Malina O, Sperling R, Mathews DH, Stoilov P, Stamm S. Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure. Nucleic Acids Res. 2013 Apr 1;41(6):3819-32. doi: 10.1093/nar/gkt063. Epub 2013 Feb 7.
PMID: 23393189
Falaleeva M, Stamm S. Processing of snoRNAs as a new source of regulatory non-coding RNAs: snoRNA fragments form a new class of functional RNAs. Bioessays. 2013 Jan;35(1):46-54. doi: 10.1002/bies.201200117. Epub 2012 Nov 26. Review.
PMID: 23180440
Kelemen O, Convertini P, Zhang Z, Wen Y, Shen M, Falaleeva M, Stamm S. Function of alternative splicing.
Gene. 2013 Feb 1;514(1):1-30. doi: 10.1016/j.gene.2012.07.083. Epub 2012 Aug 15. Review.
PMID: 22909801
Becker K, Braune M, Benderska N, Buratti E, Baralle F, Villmann C, Stamm S, Eulenburg V, Becker CM. A retroelement modifies pre-mRNA splicing: the murine Glrb(spa) allele is a splicing signal polymorphism amplified by long interspersed nuclear element insertion.
J Biol Chem. 2012 Sep 7;287(37):31185-94. doi: 10.1074/jbc.M112.375691. Epub 2012 Jul 10.
PMID: 22782896
Sumanasekera C, Kelemen O, Beullens M, Aubol BE, Adams JA, Sunkara M, Morris A, Bollen M, Andreadis A, Stamm S. C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1
Nucleic Acids Res. 2012 May;40(9):4025-39. doi: 10.1093/nar/gkr1289. Epub 2011 Dec 30.
PMID: 22210893
Shen M, Eyras E, Wu J, Khanna A, Josiah S, Rederstorff M, Zhang MQ, Stamm S. Direct cloning of double-stranded RNAs from RNase protection analysis reveals processing patterns of C/D box snoRNAs and provides evidence for widespread antisense transcript expression.
Nucleic Acids Res. 2011 Dec;39(22):9720-30. doi: 10.1093/nar/gkr684. Epub 2011 Aug 31.
PMID: 21880592
Pihlajamäki J, Lerin C, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W, Ren H, Morris AJ, Stamm S, Goldfine AB, Laakso M, Patti ME. Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis.
Cell Metab. 2011 Aug 3;14(2):208-18. doi: 10.1016/j.cmet.2011.06.007.
PMID: 21803291
Wang Y, Wang J, Gao L, Stamm S, Andreadis A. (2011). An SRp75/hnRNPG complex interacting with hnRNPE2 regulates the 5' splice site of tau exon 10, whose misregulation causes frontotemporal dementia Gene. 2011 Oct 10;485(2):130-8. doi: 10.1016/j.gene.2011.06.020. Epub 2011 Jun 30.
PMID: 21723381
Clery, A., Jayne, S., Benderska, N., Dominguez, C., Stamm, S., and Allain, F.H. (2011). Molecular basis of purine-rich RNA recognition by the human SR-like protein Tra2-beta1. Nature Structural & Molecular Biology 18, 443-450.
Zhang, Z., and Stamm, S. (2011). Analysis of mutations that influence pre-mRNA splicing. Methods Mol. Biol. 703, 137-160.
Zhang, Z., Kelemen, O., van Santen, M.A., Yelton, S.M., Wendlandt, A.E., Sviripa, V.M., Bollen, M., Beullens, M., Urlaub, H., Lührmann, R., et al. (2011). Synthesis and Characterization of Pseudocantharidins, Novel Compounds That Promote Inclusion of the SMN2 Exon 7. J Biol. Chem. 286, 10126-10136.
Kishore, S., and Stamm, S. (2011). Role of Alternative Splicing of the 5-HT2C Receptor in the Prader–Willi Syndrome. In 5-HT2C Receptors in the Pathophysiology of CNS Disease, G. Di Giovanni, E. Esposito, and V. Di Matteo, eds. (Humana Press), pp. 413-427.
Zhang, Z., Theler, D., Kaminska, K.H., Hiller, M., Grange, P.D., Pudimat, R., Rafalska, I., Heinrich, B., Bujnicki, J.M., Allain, F.H., et al. (2010). The YTH domain is a novel RNA binding domain. J Biol Chem 285, 14701-14710.
Zhang, B., zur Hausen, A., Orlowska-Volk, M., Jager, M., Bettendorf, H., Stamm, S., Hirschfeld, M., Yiqin, O., Tong, X., Gitsch, G., et al. (2010). Alternative splicing-related factor YT521: an independent prognostic factor in endometrial cancer. International journal of gynecological cancer : International Gynecol. Cancer Soc. 20, 492-499.
Tosi, M., Stamm, S., and Baralle, D. (2010). RNA splicing meets genetic testing: detection and interpretation of splicing defects in genetic diseases. Eur J Hum Genet 18, 737-738.
Pedrotti, S., Bielli, P., Paronetto, M.P., Ciccosanti, F., Fimia, G.M., Stamm, S., Manley, J.L., and Sette, C. (2010). The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy. EMBO J. 29,1235-1247.
Kishore, S., Khanna, A., Zhang, Z., Hui, J., Balwierz, P., Stefan, M., Beach, C., Nicholls,R.D., Zavolan, M., and Stamm, S. (2010). The snoRNA MBII-52 (SNORD 115) is processed intosmaller RNAs and regulates alternative splicing. Hum. Mol. Genet 19, 1153-1164.
Khanna, A., and Stamm, S. (2010). Regulation of alternative splicing by short non-codingnuclear RNAs. RNA Biol. 19, 480-485.
Benderska, N., Becker, K., Girault, J.A., Becker, C.M., Andreadis, A., and Stamm, S. (2010). DARPP-32 binds to tra2-beta1 and influences alternative splicing. Biochem Biophys. Acta 1799, 448-453.
Tazi, J., Bakkour, N., and Stamm, S. (2009). Alternative splicing and disease. Biochim BiophysActa 1792, 14-26.
Heinrich, B., Zhang, Z., Raitskin, O., Hiller, M., Benderska, N., Hartmann, A.M., Bracco, L., Elliott, D., Ben-Ari, S., Soreq, H., et al. (2009). Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. J. Biol. Chem. 284, 14303-14315.
Sumanasekera, C., Watt, D.S., and Stamm, S. (2008). Substances that can change alternative splice-site selection. Biochem Soc Trans 36, 483-490.
Stamm, S. (2008). Regulation of alternative splicing by reversible phosphorylation. J. Biol. Chem. 283, 1223-1227.
Novoyatleva, T., Heinrich, B., Tang, Y., Benderska, N., Butchbach, M.E., Lorson, C.L., Lorson,M.A., Ben-Dov, C., Fehlbaum, P., Bracco, L., Burghes, A.M.H., Bollen, M., Stamm, S. (2008).Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and
regulates alternative pre-mRNA processing. Hum Mol Genet, 52-70.
Mayer, S., zur Hausen, A., Watermann, D.O., Stamm, S., Jager, M., Gitsch, G., and Stickeler, E. (2008). Increased soluble CD44 concentrations are associated with larger tumor size and lymph node metastasis in breast cancer patients. J. Can. Res. Clin. Onc. 134, 1229-1235.
Zhang, Z., Theler, D., Kaminska, K.H., Hiller, M., de la Grange, P., Pudimat, R., Rafalska, I., Heinrich, B., Bujnicki, J.M., Allain, F.H., and Stamm, S (2010). The YTH domain is a novel RNA binding domain. Journal Biol. Chem. 285, 14701-14710.
Jingyi Hui, Shivendra Kishore, Amit Khanna, and Stefan Stamm
Analysis of Alternative Splicing with Microarrays
S.Krawetz (ed.), Bioinformatics for Systems Biology, DOl 10.1007/978-1-59745-440-7_14,
(c) Humana Press, a part of Springer Science+Business Media, LLC 2009
Kishore S, Khanna A, Stamm S.
Rapid generation of splicing reporters with pSpliceExpress.
Gene. 2008 Dec 31;427(1-2):104-10. Epub 2008 Oct 1.
PMID: 18930792 [PubMed - in process]
Ehrmann I, Dalgliesh C, Tsaousi A, Paronetto MP, Heinrich B, Kist R, Cairns P, Li W, Mueller C, Jackson M, Peters H, Nayernia K, Saunders P, Mitchell M, Stamm S, Sette C, Elliott DJ.
Haploinsufficiency for the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse.
Hum Mol Genet. 2008 Jun 18.
Hiller M, Zhang Z, Backofen R, Stamm S.
Pre-mRNA Secondary Structures Influence Exon Recognition.
PLoS Genet. 2007 Nov 16;3(11)
Conrad C, Zhu J, Conrad C, Schoenfeld D, Fang Z, Ingelsson M, Stamm S, Church G, Hyman BT.
Single molecule profiling of tau gene expression in Alzheimer's disease.
J Neurochem. 2007 Nov;103(3):1228-36.
Gromoll J, Lahrmann L, Godmann M, Müller T, Michel C, Stamm S, Simoni M.
Genomic checkpoints for exon 10 usage in the luteinizing hormone receptor type 1 and type 2.
Mol Endocrinol. 2007 Aug;21(8)
Kishore S, Stamm S.
Regulation of alternative splicing by snoRNAs.
Cold Spring Harb Symp Quant Biol. 2006;71:329-34. Review.
Novoyatleva T, Tang Y, Rafalska I, Stamm S.
Pre-mRNA missplicing as a cause of human disease.
Prog Mol Subcell Biol. 2006;44:27-46. Review.
Markus MA, Heinrich B, Raitskin O, Adams DJ, Mangs H, Goy C, Ladomery M, Sperling R, Stamm S, Morris BJ.
WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo.
Exp Cell Res. 2006
Watermann, D.O., Tang, Y., zur Hausen, A. , Jäger, M., Zhang, Z., Stamm, S. and Stickeler, E. (2006)
Splicing factor Tra2-beta1 is specifically induced in breast cancer and regulates alternative splicing of the CD44 gene,
Cancer Res.
Kishore, S and Stamm, S (2006)
The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 5-HT2CR.
Science, 311, 230-232
Stamm S., Riethoven J.-J., LeTexier V., Gopalakrishnan C., Kumanduri V., Tang Y., Barbosa-Morais N. L. and Thanaraj T. A. (2006)
ASD: A Bioinformatics Resource on Alternative Splicing.
Nucleic Acids Res, 34,D46-55.
Tse S. W., Broderick J. A., Wei M. L., Luo M. H., Smith D., McCaffery P., Stamm S. and Andreadis A. (2005)
Identification, expression analysis, genomic organization and cellular location of a novel protein with a RhoGEF domain.
Gene, 359:63-72
Glatz D. C., Rujescu D., Tang Y., Berendt F., Hartmann A. M., Faltrako F., Rosenberg C., Hulette C., Jellinger K., Hampel H., Riederer P., Möller H. J., Andreadis A., Henkel K. and Stamm S. (2006)
Alternative missplicing of microtuble associated protein tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 in Alzheimer’s disease.
J. Neurochem., 96 635-44
Wang Y, Wang J, Gao L, Lafyatis R, Stamm S, Andreadis A. (2005):
Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta 1.
J. Biol. Chem., 280 14230-14239
Thanaraj TA, Cochet O and Stamm S
Misregulation of alternative splicing as a novel target for drug intervention
Stamm, S., Ben-Ari, S., Rafalska, I., Tang, Y., Zhang, Z., Toiber, D., Thanaraj, T. A., and Soreq, H. (2005).
Function of alternative splicing.
Gene, 344C:1-20
Thanaraj, T. A., Stamm, S., Clark, F., Riethoven, J. J., Le-Texier, V.,Muilu, J. (2004)
ASD: the Alternative Splicing Database,
Nucl. Acids Res.,: 32 Database issue:D64-69
Wang, J., Gao, Q.-S., Wang, Y.C., Lafyatis, R., Stamm, S. and Andreadis, A. (2004)
Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.
J. Neurochem., 88:1078-90
Fischer, D.C., Noack, K., Runnebaum, I.B., Watermann, D.O., Kieback, D.G., Stamm, S. and Stickeler, E. (2004)
Expression of splicing factors in normal ovary and in human ovarian cancer.
Oncology Reports. 11:1085-1090
Stoilov, P., Daoud, R., Nayler, O. and Stamm, S. (2004)
Human tra2-beta1 autoregulates its protein concentration by influencing alternative splicing of its pre-mRNA.
Hum. Mol. Gen. 13:509-524
Stoss, O., Novoyatleva, T., Gencheva, M., Olbrich, M., Benderska, N. and Stamm, S. (2004): p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1.
Mol. Cell. Neurosci., 27:8-21
Rafalska, I., Zhang, Z., Benderska, N., Wolff, H., Hartmann, A.M., Brack-Werner, R. and Stamm, S.(2004):
The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation.
Hum. Mol. Genet., 13:1535-49
Münch C, Zhu BG, Leven A, Stamm S, Einkorn H, Schwalenstocker B, Ludolph AC, Riepe MW, Meyer T (2003)
Differential regulation of 5' splice variants of the glutamate transporter EAAT2 in an in vivo model of chemical hypoxia induced by 3-nitropropionic acid.
J Neurosci Res 71:819-825.
Jiang, Z., Tang, H., Havlioglu, N., Zhang, X., Stamm, S., Yan, R.,Wu, J. Y. (2003)
Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2-beta1,
J. Biol. Chem., 27:18997-19007.
Wilkinson, F.L., Holaska, J. M., Zhang, Z., Sharma, A., Manilal, S., Holt, I. , Stamm, S., Wilson, K.L. and Morris, G.L. (2003)
Emerin interacts with the splicing associated factor, YT521-B
Eur. J. Biochem. 270:2459-66
Thanaraj, T.A. and S. Stamm (2003)
Prediction and statistical analysis of alternatively spliced exons.
Prog. Mol. Sub. Biol. 31:1-31
Stamm, S (2002)
Signals and their transduction pathways regulating alternative splicing.
Hum. Mol. Genet., 11: 2409-2416
Haapasalo A, Sipola I, Larsson K, Akerman KE, Stoilov P, Stamm S, Wong G and Castren E. (2002)
Regulation of TrkB surface expression by brain-derived neurotrophic factor and truncated TrkB isoforms.
J. Biol. Chem.: 277: 43160-43167
Stoilov, P., Meshorer, E., Gencheva, M., Glick, D., Soreq, H. and Stamm, S. (2002)
Defects in pre-mRNA processing as causes and predispositions to diseases,
DNA and Cell Biology, 21(11):803-18
Arikan, M.C., Memmott, J., Broderick, J.A., Lafyatis, R., Screaton, G., Stamm, S. and Andreadis, A. (2002)
Modulation of the membrane-binding projection domain of tau protein: splicing regulation of exon 3.
Brain Res Mol Brain Res, 101, 109-121
Münch, C.; Ebstein, M.; Seefried, U.; Zhu, B.; Stamm, S.;Landwehrmeyer, G.B.; Ludolph, A.C.; Schwalenstöcker, B. andMeyer, T. ( 2002)
Alterantive splicing of the 5'-sequences of themouse EAAT2 glutamate transporter and expression in a transgenicmodel for amyotrophic lateral sclerosis,
J. Neurochem.: 82:594-603
Stoilov, P., Rafalska, I. and Stamm, S. (2002)
YTH: a new domain in nuclear proteins.
Trends Biol. Sci. 27: 495-496
Daoud, R., G. Mies, L. Kopczynska, A., Oláh, K. Hossmann, and S. Stamm (2002)
Ischemia induces a translocation of the splicingfactor tra2-beta1 and changes alternative splicing patterns in the brain.
J. Neurosci.: 22: 5889-5899
Stoilov, P., Castren, E., and S. Stamm. (2002)
Analysis of the human TrkBgene organisation reveals novel trkB isoforms, unusual gene length and splicing mechanism, Biophy.
Biochem,.Res. Comun. 290:1054-1065
Nikolakaki, E., R. Kohen, A.M. Hartmann, S. Stamm, E.Georgatsou, and T. Giannakouros. (2001)
Alternative splicing of SRprotein-specific kinase 1 - SRPK1a interacts specifically with Scaffold Attachment Factor-B.
J. Biol. Chem. 276: 40175-40182
Rujescu, D., Hartmann, A.M. und Stamm S. (2001)
Alternatives Spleißen: Wie der Mensch aus 35.000 Genen 250.000 Proteinemacht.
Bioforum 24: 830-834 (in German)
Adams, D.J., Weyden, L.v.d., Mayeda, A., Stamm, S., Morris, B.J., and Rasko, J.E.J., (2001)
ZNF265-A novel spliceosomal protein able to induce alternative splicing.
J. Cell Biol., 154: 25-32
Hartmann, A., D. Rujescu, T. Giannakouros, E. Nikolakaki, M. Goedert, E. Mandelkow, Q.S. Gao, A. Andreadis, and S. Stamm. (2001)
Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors.
Mol. Cell. Neurosci.:18,80-90
Stoss, O., M. Olbrich, A.M. Hartmann, H. König, J. Memmott, A. Andreadis, and S. Stamm. (2001)
The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites.
J. Biol. Chem. 276:8665-8673.
Daoud, R., P. Stoilov, O. Stoss, A.M. Hartmann, M. Olbrich, and S. Stamm. (2000)
Control of pre-mRNA processing by extracellular signals: from molecular mechanisms to clinical applications.
Gene Ther. Mol. Biol. 5: 141-150.
Stoss, O., Stoilov, P., Daoud, R., Hartmann, A.M., Olbrich, M. and Stamm, S. (2000)
Misregulation of pre-mRNA splicing that causes human diseases.
Gene Ther. Mol. Biol. 5: 9-28
Nayler, O., Hartmann, A.M., Stamm, S. (2000)
The ER-repeat protein YT521-B localizes to a novel subnuclear compartment,
J. Cell Biol., 150: 949-961
Nehring, R.B., Horikawa, H.P., El Far, O,,Kneussel, M., Brandstatter, J.H., Stamm, S., Wischmeyer, E,, Betz, H., Karschin, (2000) The Metabotropic GABAB Receptor Directly Interacts with the Activating Transcription Factor 4 (ATF-4), J. Biol. Chem. 275:35185-35191
Poleev, A., Hartmann, A. and Stamm, S. (2000)
A trans-acting factor, isolated by the three hybrid system, that influences alternative splicing of the amyloid precursor protein minigene.
Eur. J. Biochem. 267: 4002-4010
Münch, C., Schwalenstöcker, B., Hermann, C., Cirovic, S., Stamm, S., Ludolph, A., Meyer, T. (2000)
Differential RNA cleavage and polyadenylation of the glutamate transporter EAAT2 in the human brain.
Mol. Brain Res. 80:244-251
Stamm, S., Zhu, J., Nakai, K., Stoilov, P., Stoss, O. and Zhang, M.Q. (2000)
An alternative exon database (AEDB) and its statistical analysis,
DNA and Cell Biol.,19:739-756
Hofmann, Y., Lorson, C.L., Stamm, S., Androphy, E.J. and Wirth, B. (2000)
Htra2-beta1 stimulates an exonic splicing enhancer and can restore full- length SMN expression to survival motor neuron 2 (SMN2),
Proc. Natl. Acad. Sci. USA 97:9618-9623
Hirsch, E., Oohashi, T., Ahmad, M., Stamm, S. and Fässler, R., (2000)
Peri-Implantation lethality in mice lacking the Sm motif-containing protein Lsm4,
Mol. Cell. Biol., 20:1055-1062
Gao, Q.-S., Memmott, J., Lafyatis, R., Stamm, S., Screaton, G. and Andreadis, A. (2000)
Complex regulation of tau exon 10, whose missplicing causes frontotemporal dementia.,
kjh., 74: 490-500
Meyer, T., Fromm, A., Münch, C., Schwalenstöcker, B., Fray, A.E., Ince, P.G., Stamm, S., Völkel, H., Ludolph, A.C., and Shaw, P.J., (1999)
The RNA of the glutamate transporter EAAT2 is variably spliced in amyotrophic lateral sclerosis and normal individuals.
J.Neurol. Sci., 170: 45-50
Hartmann, A.M., Nayler, O., Schwaiger, F.W., Obermeier, A. and Stamm, S., (1999)
The interaction and colocalisation of Sam68 with the splicing associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59fyn
Mol. Biol. Cell.,10: 3909-3926
Stoss, O., Stoilov, P., Hartmann, A.M., Nayler, O. and Stamm, S., (1999)
The in vivo minigene approach to analyze tissue-specific splicing,
Brain Res. Prot., 3:383-394
Nayler, O. and Stamm, S., (1999)
ScienceLabDatabase: A computer program to organise a molecular biology laboratory.
Biotechniques 26: 1186-1191
Stoss, O., Schwaiger, F.W., Cooper, T.A., and Stamm, S., (1999)
Alternative splicing determines the intracellular localization of the novel muscle-specific protein Nop30 and its interaction with the splicing factor SRp30c.
J. Biol. Chem.,274: 10951-10962.
Stamm, S., Casper, D., Hanson, V., and Helfman, D.M., (1999)
Regulation of the neuron-specific exon of clathrin light chain B.
Mol. Brain Res., 64: 108-118
Daoud, R., Berzaghi, M., Siedler, F., Hübener, M., and Stamm, S., (1999)
Activity dependent regulation of alternative splicing patterns in the rat brain.
Eur. J. Neurosci., 11: 788-802
Nayler, O., Schnorrer, F., Stamm, S., Ullrich, A., (1998)
The cellular localisation of the SR protein kinase mCLK2 is regulated by serine 141 autophosphorylation.
J. Biol. Chem., 273: 34341-34348
Nayler, O., Cap, C. and Stamm , S. (1998)
Human transformer-2-beta gene: Complete nucleotide sequence, chromosomal localisation and generation of a tissue specific isoform.
Genomics 53, p. 191-202
Nayler, O., Strätling, W., Bourquin, J.-P., Stagljar, I., Lindemann, L., Jasper, H., Hartmann, A.M., Fackelmeyer, F.O., Ullrich, A., and Stamm, S. (1998)
SAF-B couples transcription and pre-mRNA splicing to SAR/MAR elements.
Nucl. Acids Res., . 26: p. 3542-3549.
Hartmann, A.M. and Stamm, S. (1997)
Molecular cloning of a novel alternatively spliced nuclear protein.
Biochem. Biophys. Res. Com., 1353: p. 224-230.
Nayler, O., Stamm, S., and Ullrich, A. (1997)
Characterisation and comparison of four SR protein kinases.
Biochem. J., 326: p. 693-700.
Beil, B., Screaton, G. and Stamm, S. (1997)
Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologues of tra-2 generated by alternative splicing.
DNA 16: 679-690
Stamm, S. and Brosius, J. (1995) Solid Phase PCR. in PCR II - A practical Approach. Oxford University Press. 55-70.
Cáceres, J., Stamm, S., Helfman, D.M. and Krainer, A.R. (1994)
Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors.
Science 265: 1706-1709. Stamm, S., Zhang, M.Q., Marr, T.G. and Helfman, D.M. (1994)
A sequence compilation and
comparison of exons that are alternatively spliced in neurons.
Nucl. Acids Res. 22: 1515-1526.
Stamm, S., G. J. Mulligan, A. R. Krainer and D. M. Helfman. (1994)
Non-radioactive RNAs by immunoblotting
Nucl. Acids Res. 22, 252-253
Stamm, S., D. Casper, J.P. Lees-Miller and D.M. Helfman. (1993)
Brain-specific Tropomyosins TMBr-1 and TMBr-3 have distinct patterns of expression during development and in adult brain Proc.
Natl. Acad. Sci. USA 90: 9857-9861
Miller, M.W. , S. Beushausen, A. Vitek, S. Stamm, I. Kupfermann, J. Brosius, and K.R. Weiss. (1993)
The Myomodulin-related Neuropeptides: Characterization of a Gene Encoding a Family of Peptide Cotransmitters in Aplysia
J. Neurosci. 13, 3358-3367
Miller, M.W., S. Beushausen, E.C. Cropper, K. Eisinger, S. Stamm, F.S. Vilim, A. Vitek, A. Zajc, I. Kupfermann, J. Brosius, and K.R. Weiss. (1993)
The Buccalin-related Neuropeptides: Isolation and Characterization of an Aplysia cDNA Clone encoding a Family of Peptide Cotransmitters.
J. Neurosci. 13, 3346-3357
Stamm, S. , D. Casper, J. Dinsmore, C. A. Kaufmann, J. Brosius and D. M. Helfman. (1992)
Clathrin Light Chain B: Gene structure and neuron-specific splicing.
Nucl. Acids Res. 19, 5097 - 5103
Kelly, K.A., S. Stamm and C.A. Kozak. (1992)
Expression and Chromosomal Localization of the Murine Cystic Fibrosis Transmembrane Conductance Regulator,
Genomics 13, 381- 388
Stamm, S., Gillo, B. and Brosius, J. (1991)
Temperature Recording from Thermocyclers used for PCR
Biotechniques 10, 430- 435
Stamm, S. and J. Brosius (1991)
Sanchored PCR
Nucl. Acids Res. 19, 1350
Stamm, S. and F M. Longo (1989)
Direct Sequencing of PCR Products Using the Maxam- Gilbert Method
GATA 7 142 - 143
Welden JR, Margvelani G, Arizaca Maquera KA, Gudlavalleti B, Miranda Sardón SC, Campos A, Robil N, Lee DC, Gonzalo Hernandez A, Wang W, Di J, de la Grange P, Nelson PT, Stamm S. RNA editing of microtubule associated protein tau circular RNAs promotes their translation and tau tangle formation. Nucleic Acids Res. 2022 Dec 9;50(22):12979-12996
Hart SN, Patel SP, Michael FM, Stoilov P, Leow CJ, Hernandez AG, Jolly A, de la Grange P, Rabchevsky AG, Stamm S. Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns. Neurotrauma Rep. 2022;3(1):105-21. Epub 2022/04/12. doi: 10.1089/neur.2021.0042. PubMed PMID: 35403103; PMCID: PMC8985541.
Tubero Euzebio Alves V, Al-Attar A, Alimova Y, Maynard MH, Kirakodu S, Martinez-Porras A, Hawk GS, Ebersole JL, Stamm S, Gonzalez OA. Streptococcus gordonii-Induced miRNAs Regulate CCL20 Responses in Human Oral Epithelial Cells. Infect Immun. 2022;90(3):e0058621. Epub 2022/02/01. doi: 10.1128/iai.00586-21. PubMed PMID: 35099275; PMCID: PMC8929334.
Welden, J.R., Pawluchin, A., van Doorn, J., Stamm, S. Use of Alu Element Containing Minigenes to Analyze Circular RNAs. J. Vis. Exp.(157), e59760, doi:10.3791/59760 (2020).
Welden JR, Stamm S. Pre-mRNA structures forming circular RNAs. Biochim Biophys Acta Gene Regul Mech. 2019 Nov - Dec;1862(11-12):194410.
Stamm S, Lodmell JS. C/D box snoRNAs in viral infections: RNA viruses use old dogs for new tricks. Noncoding RNA Res. 2019;4(2):46-53.
Welden JR, Zhang Z, Duncan MJ, Falaleeva M, Wells T, Stamm S. The posterior pituitary expresses the serotonin receptor 2C. Neurosci Lett. 2018;684:132-9.
Welden JR, van Doorn J, Nelson PT, Stamm S. The human MAPT locus generates circular RNAs. Biochim Biophys Acta Mol Basis Dis. 2018;1864(9 Pt B):2753-60.
Falaleeva M, Welden JR, Duncan MJ, Stamm S. C/D-box snoRNAs form methylating and non-methylating ribonucleoprotein complexes: Old dogs show new tricks. Bioessays. 2017;39(6).
Thurman M, van Doorn J, Danzer B, Webb TR, Stamm S. Changes in Alternative Splicing as Pharmacodynamic Markers for Sudemycin D6. Biomark Insights. 2017;12:1177271917730557.
Stamm S, Gruber SB, Rabchevsky AG, Emeson RB. The activity of the serotonin receptor 2C is regulated by alternative splicing. Hum Genet. 2017.
Webb TR, Stamm S. Targeting Pre-mRNA Processing in Cancer. Comprehensive Medicinal Chemistry, 3rd Edition. 2017.
Stamm S. Alternative splicing and human disease. Enzcyclopedia of Life Sciences. 2017.
Falaleeva M, Pages A, Matuszek Z, Hidmi S, Agranat-Tamir L, Korotkov K, Nevo Y, Eyras E, Sperling R, Stamm S. Dual function of C/D box snoRNAs in rRNA modification and alternative pre-mRNA splicing Proc Natl Acad Sci U S A. 2016;113(12):E1625-34.PubMed PMID: 26957605.
Zhang Z, Shen M, Gresch P, Ghamari-Langroudi M, Rabchevsky AG, Emeson RB, Stamm S. Oligonucleotide-induced alternative splicing of serotonin 2C receptor reduces food intake. EMBO molecular medicine. 2016;8(8):878-94.PubMed PMID: 27406820.
Matveeva E, Maiorano J, Zhang Q, Eteleeb AM, Convertini P, Chen J, Infantino V, Stamm S, Wang J, Rouchka EC, Fondufe-Mittendorf YN. Involvement of PARP1 in the regulation of alternative splicing. Cell discovery. 2016;2:15046. PubMed PMID: 27462443.
Kwiatkowski S, Sviripa VM, Zhang Z, Wendlandt AE, Hobartner C, Watt DS, Stamm S. Synthesis of a norcantharidin-tethered guanosine: Protein phosphatase-1 inhibitors that change alternative splicing. Bioorganic & medicinal chemistry letters. 2016;26(3):965-8.PubMed PMID: 26725024
- Pubmed
- PDF File
Falaleeva, M., Surface, J., Shen, M., de la Grange, P. and Stamm, S. SNORD116 and SNORD115 change expression of multiple genes and modify each other's activity. Gene (2015).
Shi Y, Joyner AS, Shadrick W, Palacios G, Lagisetti C, Potter PM, Sambucetti LC, Stamm S, Webb TR. Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates. Pharmacology research & perspectives. 2015;3(4):e00158.PubMed PMID: 26171237.
Jamros, M.A., Aubol, B.E., Keshwani, M.M., Zhang, Z., Stamm, S. and Adams, J.A. Intra-domain cross talk regulates serine-arginine protein kinase 1 dependent phosphorylation and splicing function of transformer 2 beta 1. J. Biol. Chem. (2015).
Shen M, Falaleeva M, Korotkova N, & Stamm S (2015) Direct cloning of double-stranded RNAs. Methods in Molecular Biology 1296:53-64. PMID: 25791590
- Pubmed
- PDF File
Convertini P, Shen M, Potter PM, Palacios G, Lagisetti C, de la Grange P, Horbinski C, Fondufe-Mittendorf YN, Webb TR, Stamm S. Sudemycin E influences alternative splicing and changes chromatin modifications. Nucleic Acids Res. 2014 Apr;42(8):4947-61. doi: 10.1093/nar/gku151. Epub 2014 Mar 11.
PMID: 24623796
Zhang Z, Convertini P, Shen M, Xu X, Lemoine F, de la Grange P, Andres DA, Stamm S. Valproic acid causes proteasomal degradation of DICER and influences miRNA expression. PLoS One. 2013 Dec 17;8(12):e82895. doi: 10.1371/journal.pone.0082895. eCollection 2013.
PMID: 24358235
Hirschfeld M, Zhang B, Jaeger M, Stamm S, Erbes T, Mayer S, Tong X, Stickeler E. Hypoxia-dependent mRNA expression pattern of splicing factor YT521 and its impact on oncological important target gene expression. Mol Carcinog. 2013 Jun 13. doi: 10.1002/mc.22045.
PMID: 23765422
Falaleeva M, Sulsona CR, Zielke HR, Currey KM, de la Grange P, Aslanzadeh V, Driscoll DJ, Stamm S. Molecular characterization of a patient presumed to have prader-willi syndrome. Clin Med Insights Case Rep. 2013 May 5;6:79-86. doi: 10.4137/CCRep.S11510. Print 2013.
PMID: 23700380
Convertini P, Zhang J, de la Grange P, Hayward LJ, Zhu H, Stamm S. Genome wide array analysis indicates that an amyotrophic lateral sclerosis mutation of FUS causes an early increase of CAMK2N2 in vitro. Biochim Biophys Acta. 2013 Aug;1832(8):1129-35. doi: 10.1016/j.bbadis.2013.03.015. Epub 2013 Mar 29.
PMID: 23545117
Zhang Z, Falaleeva M, Agranat-Tamir L, Pages A, Eyras E, Sperling J, Sperling R, Stamm S. The 5' untranslated region of the serotonin receptor 2C pre-mRNA generates miRNAs and is expressed in non-neuronal cells. Exp Brain Res. 2013 Oct;230(4):387-94. doi: 10.1007/s00221-013-3458-8. Epub 2013 Mar 15.
PMID: 23494383
Shen M, Bellaousov S, Hiller M, de La Grange P, Creamer TP, Malina O, Sperling R, Mathews DH, Stoilov P, Stamm S. Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure. Nucleic Acids Res. 2013 Apr 1;41(6):3819-32. doi: 10.1093/nar/gkt063. Epub 2013 Feb 7.
PMID: 23393189
Falaleeva M, Stamm S. Processing of snoRNAs as a new source of regulatory non-coding RNAs: snoRNA fragments form a new class of functional RNAs. Bioessays. 2013 Jan;35(1):46-54. doi: 10.1002/bies.201200117. Epub 2012 Nov 26. Review.
PMID: 23180440
Kelemen O, Convertini P, Zhang Z, Wen Y, Shen M, Falaleeva M, Stamm S. Function of alternative splicing.
Gene. 2013 Feb 1;514(1):1-30. doi: 10.1016/j.gene.2012.07.083. Epub 2012 Aug 15. Review.
PMID: 22909801
Becker K, Braune M, Benderska N, Buratti E, Baralle F, Villmann C, Stamm S, Eulenburg V, Becker CM. A retroelement modifies pre-mRNA splicing: the murine Glrb(spa) allele is a splicing signal polymorphism amplified by long interspersed nuclear element insertion.
J Biol Chem. 2012 Sep 7;287(37):31185-94. doi: 10.1074/jbc.M112.375691. Epub 2012 Jul 10.
PMID: 22782896
Sumanasekera C, Kelemen O, Beullens M, Aubol BE, Adams JA, Sunkara M, Morris A, Bollen M, Andreadis A, Stamm S. C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1
Nucleic Acids Res. 2012 May;40(9):4025-39. doi: 10.1093/nar/gkr1289. Epub 2011 Dec 30.
PMID: 22210893
Shen M, Eyras E, Wu J, Khanna A, Josiah S, Rederstorff M, Zhang MQ, Stamm S. Direct cloning of double-stranded RNAs from RNase protection analysis reveals processing patterns of C/D box snoRNAs and provides evidence for widespread antisense transcript expression.
Nucleic Acids Res. 2011 Dec;39(22):9720-30. doi: 10.1093/nar/gkr684. Epub 2011 Aug 31.
PMID: 21880592
Pihlajamäki J, Lerin C, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W, Ren H, Morris AJ, Stamm S, Goldfine AB, Laakso M, Patti ME. Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis.
Cell Metab. 2011 Aug 3;14(2):208-18. doi: 10.1016/j.cmet.2011.06.007.
PMID: 21803291
Wang Y, Wang J, Gao L, Stamm S, Andreadis A. (2011). An SRp75/hnRNPG complex interacting with hnRNPE2 regulates the 5' splice site of tau exon 10, whose misregulation causes frontotemporal dementia Gene. 2011 Oct 10;485(2):130-8. doi: 10.1016/j.gene.2011.06.020. Epub 2011 Jun 30.
PMID: 21723381
Clery, A., Jayne, S., Benderska, N., Dominguez, C., Stamm, S., and Allain, F.H. (2011). Molecular basis of purine-rich RNA recognition by the human SR-like protein Tra2-beta1. Nature Structural & Molecular Biology 18, 443-450.
Zhang, Z., and Stamm, S. (2011). Analysis of mutations that influence pre-mRNA splicing. Methods Mol. Biol. 703, 137-160.
Zhang, Z., Kelemen, O., van Santen, M.A., Yelton, S.M., Wendlandt, A.E., Sviripa, V.M., Bollen, M., Beullens, M., Urlaub, H., Lührmann, R., et al. (2011). Synthesis and Characterization of Pseudocantharidins, Novel Compounds That Promote Inclusion of the SMN2 Exon 7. J Biol. Chem. 286, 10126-10136.
Kishore, S., and Stamm, S. (2011). Role of Alternative Splicing of the 5-HT2C Receptor in the Prader–Willi Syndrome. In 5-HT2C Receptors in the Pathophysiology of CNS Disease, G. Di Giovanni, E. Esposito, and V. Di Matteo, eds. (Humana Press), pp. 413-427.
Zhang, Z., Theler, D., Kaminska, K.H., Hiller, M., Grange, P.D., Pudimat, R., Rafalska, I., Heinrich, B., Bujnicki, J.M., Allain, F.H., et al. (2010). The YTH domain is a novel RNA binding domain. J Biol Chem 285, 14701-14710.
Zhang, B., zur Hausen, A., Orlowska-Volk, M., Jager, M., Bettendorf, H., Stamm, S., Hirschfeld, M., Yiqin, O., Tong, X., Gitsch, G., et al. (2010). Alternative splicing-related factor YT521: an independent prognostic factor in endometrial cancer. International journal of gynecological cancer : International Gynecol. Cancer Soc. 20, 492-499.
Tosi, M., Stamm, S., and Baralle, D. (2010). RNA splicing meets genetic testing: detection and interpretation of splicing defects in genetic diseases. Eur J Hum Genet 18, 737-738.
Pedrotti, S., Bielli, P., Paronetto, M.P., Ciccosanti, F., Fimia, G.M., Stamm, S., Manley, J.L., and Sette, C. (2010). The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy. EMBO J. 29,1235-1247.
Kishore, S., Khanna, A., Zhang, Z., Hui, J., Balwierz, P., Stefan, M., Beach, C., Nicholls,R.D., Zavolan, M., and Stamm, S. (2010). The snoRNA MBII-52 (SNORD 115) is processed intosmaller RNAs and regulates alternative splicing. Hum. Mol. Genet 19, 1153-1164.
Khanna, A., and Stamm, S. (2010). Regulation of alternative splicing by short non-codingnuclear RNAs. RNA Biol. 19, 480-485.
Benderska, N., Becker, K., Girault, J.A., Becker, C.M., Andreadis, A., and Stamm, S. (2010). DARPP-32 binds to tra2-beta1 and influences alternative splicing. Biochem Biophys. Acta 1799, 448-453.
Tazi, J., Bakkour, N., and Stamm, S. (2009). Alternative splicing and disease. Biochim BiophysActa 1792, 14-26.
Heinrich, B., Zhang, Z., Raitskin, O., Hiller, M., Benderska, N., Hartmann, A.M., Bracco, L., Elliott, D., Ben-Ari, S., Soreq, H., et al. (2009). Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. J. Biol. Chem. 284, 14303-14315.
Sumanasekera, C., Watt, D.S., and Stamm, S. (2008). Substances that can change alternative splice-site selection. Biochem Soc Trans 36, 483-490.
Stamm, S. (2008). Regulation of alternative splicing by reversible phosphorylation. J. Biol. Chem. 283, 1223-1227.
Novoyatleva, T., Heinrich, B., Tang, Y., Benderska, N., Butchbach, M.E., Lorson, C.L., Lorson,M.A., Ben-Dov, C., Fehlbaum, P., Bracco, L., Burghes, A.M.H., Bollen, M., Stamm, S. (2008).Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and
regulates alternative pre-mRNA processing. Hum Mol Genet, 52-70.
Mayer, S., zur Hausen, A., Watermann, D.O., Stamm, S., Jager, M., Gitsch, G., and Stickeler, E. (2008). Increased soluble CD44 concentrations are associated with larger tumor size and lymph node metastasis in breast cancer patients. J. Can. Res. Clin. Onc. 134, 1229-1235.
Zhang, Z., Theler, D., Kaminska, K.H., Hiller, M., de la Grange, P., Pudimat, R., Rafalska, I., Heinrich, B., Bujnicki, J.M., Allain, F.H., and Stamm, S (2010). The YTH domain is a novel RNA binding domain. Journal Biol. Chem. 285, 14701-14710.
Jingyi Hui, Shivendra Kishore, Amit Khanna, and Stefan Stamm
Analysis of Alternative Splicing with Microarrays
S.Krawetz (ed.), Bioinformatics for Systems Biology, DOl 10.1007/978-1-59745-440-7_14,
(c) Humana Press, a part of Springer Science+Business Media, LLC 2009
Kishore S, Khanna A, Stamm S.
Rapid generation of splicing reporters with pSpliceExpress.
Gene. 2008 Dec 31;427(1-2):104-10. Epub 2008 Oct 1.
PMID: 18930792 [PubMed - in process]
Ehrmann I, Dalgliesh C, Tsaousi A, Paronetto MP, Heinrich B, Kist R, Cairns P, Li W, Mueller C, Jackson M, Peters H, Nayernia K, Saunders P, Mitchell M, Stamm S, Sette C, Elliott DJ.
Haploinsufficiency for the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse.
Hum Mol Genet. 2008 Jun 18.
Hiller M, Zhang Z, Backofen R, Stamm S.
Pre-mRNA Secondary Structures Influence Exon Recognition.
PLoS Genet. 2007 Nov 16;3(11)
Conrad C, Zhu J, Conrad C, Schoenfeld D, Fang Z, Ingelsson M, Stamm S, Church G, Hyman BT.
Single molecule profiling of tau gene expression in Alzheimer's disease.
J Neurochem. 2007 Nov;103(3):1228-36.
Gromoll J, Lahrmann L, Godmann M, Müller T, Michel C, Stamm S, Simoni M.
Genomic checkpoints for exon 10 usage in the luteinizing hormone receptor type 1 and type 2.
Mol Endocrinol. 2007 Aug;21(8)
Kishore S, Stamm S.
Regulation of alternative splicing by snoRNAs.
Cold Spring Harb Symp Quant Biol. 2006;71:329-34. Review.
Novoyatleva T, Tang Y, Rafalska I, Stamm S.
Pre-mRNA missplicing as a cause of human disease.
Prog Mol Subcell Biol. 2006;44:27-46. Review.
Markus MA, Heinrich B, Raitskin O, Adams DJ, Mangs H, Goy C, Ladomery M, Sperling R, Stamm S, Morris BJ.
WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo.
Exp Cell Res. 2006
Watermann, D.O., Tang, Y., zur Hausen, A. , Jäger, M., Zhang, Z., Stamm, S. and Stickeler, E. (2006)
Splicing factor Tra2-beta1 is specifically induced in breast cancer and regulates alternative splicing of the CD44 gene,
Cancer Res.
Kishore, S and Stamm, S (2006)
The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 5-HT2CR.
Science, 311, 230-232
Stamm S., Riethoven J.-J., LeTexier V., Gopalakrishnan C., Kumanduri V., Tang Y., Barbosa-Morais N. L. and Thanaraj T. A. (2006)
ASD: A Bioinformatics Resource on Alternative Splicing.
Nucleic Acids Res, 34,D46-55.
Tse S. W., Broderick J. A., Wei M. L., Luo M. H., Smith D., McCaffery P., Stamm S. and Andreadis A. (2005)
Identification, expression analysis, genomic organization and cellular location of a novel protein with a RhoGEF domain.
Gene, 359:63-72
Glatz D. C., Rujescu D., Tang Y., Berendt F., Hartmann A. M., Faltrako F., Rosenberg C., Hulette C., Jellinger K., Hampel H., Riederer P., Möller H. J., Andreadis A., Henkel K. and Stamm S. (2006)
Alternative missplicing of microtuble associated protein tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 in Alzheimer’s disease.
J. Neurochem., 96 635-44
Wang Y, Wang J, Gao L, Lafyatis R, Stamm S, Andreadis A. (2005):
Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta 1.
J. Biol. Chem., 280 14230-14239
Thanaraj TA, Cochet O and Stamm S
Misregulation of alternative splicing as a novel target for drug intervention
Stamm, S., Ben-Ari, S., Rafalska, I., Tang, Y., Zhang, Z., Toiber, D., Thanaraj, T. A., and Soreq, H. (2005).
Function of alternative splicing.
Gene, 344C:1-20
Thanaraj, T. A., Stamm, S., Clark, F., Riethoven, J. J., Le-Texier, V.,Muilu, J. (2004)
ASD: the Alternative Splicing Database,
Nucl. Acids Res.,: 32 Database issue:D64-69
Wang, J., Gao, Q.-S., Wang, Y.C., Lafyatis, R., Stamm, S. and Andreadis, A. (2004)
Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.
J. Neurochem., 88:1078-90
Fischer, D.C., Noack, K., Runnebaum, I.B., Watermann, D.O., Kieback, D.G., Stamm, S. and Stickeler, E. (2004)
Expression of splicing factors in normal ovary and in human ovarian cancer.
Oncology Reports. 11:1085-1090
Stoilov, P., Daoud, R., Nayler, O. and Stamm, S. (2004)
Human tra2-beta1 autoregulates its protein concentration by influencing alternative splicing of its pre-mRNA.
Hum. Mol. Gen. 13:509-524
Stoss, O., Novoyatleva, T., Gencheva, M., Olbrich, M., Benderska, N. and Stamm, S. (2004): p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1.
Mol. Cell. Neurosci., 27:8-21
Rafalska, I., Zhang, Z., Benderska, N., Wolff, H., Hartmann, A.M., Brack-Werner, R. and Stamm, S.(2004):
The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation.
Hum. Mol. Genet., 13:1535-49
Münch C, Zhu BG, Leven A, Stamm S, Einkorn H, Schwalenstocker B, Ludolph AC, Riepe MW, Meyer T (2003)
Differential regulation of 5' splice variants of the glutamate transporter EAAT2 in an in vivo model of chemical hypoxia induced by 3-nitropropionic acid.
J Neurosci Res 71:819-825.
Jiang, Z., Tang, H., Havlioglu, N., Zhang, X., Stamm, S., Yan, R.,Wu, J. Y. (2003)
Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2-beta1,
J. Biol. Chem., 27:18997-19007.
Wilkinson, F.L., Holaska, J. M., Zhang, Z., Sharma, A., Manilal, S., Holt, I. , Stamm, S., Wilson, K.L. and Morris, G.L. (2003)
Emerin interacts with the splicing associated factor, YT521-B
Eur. J. Biochem. 270:2459-66
Thanaraj, T.A. and S. Stamm (2003)
Prediction and statistical analysis of alternatively spliced exons.
Prog. Mol. Sub. Biol. 31:1-31
Stamm, S (2002)
Signals and their transduction pathways regulating alternative splicing.
Hum. Mol. Genet., 11: 2409-2416
Haapasalo A, Sipola I, Larsson K, Akerman KE, Stoilov P, Stamm S, Wong G and Castren E. (2002)
Regulation of TrkB surface expression by brain-derived neurotrophic factor and truncated TrkB isoforms.
J. Biol. Chem.: 277: 43160-43167
Stoilov, P., Meshorer, E., Gencheva, M., Glick, D., Soreq, H. and Stamm, S. (2002)
Defects in pre-mRNA processing as causes and predispositions to diseases,
DNA and Cell Biology, 21(11):803-18
Arikan, M.C., Memmott, J., Broderick, J.A., Lafyatis, R., Screaton, G., Stamm, S. and Andreadis, A. (2002)
Modulation of the membrane-binding projection domain of tau protein: splicing regulation of exon 3.
Brain Res Mol Brain Res, 101, 109-121
Münch, C.; Ebstein, M.; Seefried, U.; Zhu, B.; Stamm, S.;Landwehrmeyer, G.B.; Ludolph, A.C.; Schwalenstöcker, B. andMeyer, T. ( 2002)
Alterantive splicing of the 5'-sequences of themouse EAAT2 glutamate transporter and expression in a transgenicmodel for amyotrophic lateral sclerosis,
J. Neurochem.: 82:594-603
Stoilov, P., Rafalska, I. and Stamm, S. (2002)
YTH: a new domain in nuclear proteins.
Trends Biol. Sci. 27: 495-496
Daoud, R., G. Mies, L. Kopczynska, A., Oláh, K. Hossmann, and S. Stamm (2002)
Ischemia induces a translocation of the splicingfactor tra2-beta1 and changes alternative splicing patterns in the brain.
J. Neurosci.: 22: 5889-5899
Stoilov, P., Castren, E., and S. Stamm. (2002)
Analysis of the human TrkBgene organisation reveals novel trkB isoforms, unusual gene length and splicing mechanism, Biophy.
Biochem,.Res. Comun. 290:1054-1065
Nikolakaki, E., R. Kohen, A.M. Hartmann, S. Stamm, E.Georgatsou, and T. Giannakouros. (2001)
Alternative splicing of SRprotein-specific kinase 1 - SRPK1a interacts specifically with Scaffold Attachment Factor-B.
J. Biol. Chem. 276: 40175-40182
Rujescu, D., Hartmann, A.M. und Stamm S. (2001)
Alternatives Spleißen: Wie der Mensch aus 35.000 Genen 250.000 Proteinemacht.
Bioforum 24: 830-834 (in German)
Adams, D.J., Weyden, L.v.d., Mayeda, A., Stamm, S., Morris, B.J., and Rasko, J.E.J., (2001)
ZNF265-A novel spliceosomal protein able to induce alternative splicing.
J. Cell Biol., 154: 25-32
Hartmann, A., D. Rujescu, T. Giannakouros, E. Nikolakaki, M. Goedert, E. Mandelkow, Q.S. Gao, A. Andreadis, and S. Stamm. (2001)
Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors.
Mol. Cell. Neurosci.:18,80-90
Stoss, O., M. Olbrich, A.M. Hartmann, H. König, J. Memmott, A. Andreadis, and S. Stamm. (2001)
The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites.
J. Biol. Chem. 276:8665-8673.
Daoud, R., P. Stoilov, O. Stoss, A.M. Hartmann, M. Olbrich, and S. Stamm. (2000)
Control of pre-mRNA processing by extracellular signals: from molecular mechanisms to clinical applications.
Gene Ther. Mol. Biol. 5: 141-150.
Stoss, O., Stoilov, P., Daoud, R., Hartmann, A.M., Olbrich, M. and Stamm, S. (2000)
Misregulation of pre-mRNA splicing that causes human diseases.
Gene Ther. Mol. Biol. 5: 9-28
Nayler, O., Hartmann, A.M., Stamm, S. (2000)
The ER-repeat protein YT521-B localizes to a novel subnuclear compartment,
J. Cell Biol., 150: 949-961
Nehring, R.B., Horikawa, H.P., El Far, O,,Kneussel, M., Brandstatter, J.H., Stamm, S., Wischmeyer, E,, Betz, H., Karschin, (2000) The Metabotropic GABAB Receptor Directly Interacts with the Activating Transcription Factor 4 (ATF-4), J. Biol. Chem. 275:35185-35191
Poleev, A., Hartmann, A. and Stamm, S. (2000)
A trans-acting factor, isolated by the three hybrid system, that influences alternative splicing of the amyloid precursor protein minigene.
Eur. J. Biochem. 267: 4002-4010
Münch, C., Schwalenstöcker, B., Hermann, C., Cirovic, S., Stamm, S., Ludolph, A., Meyer, T. (2000)
Differential RNA cleavage and polyadenylation of the glutamate transporter EAAT2 in the human brain.
Mol. Brain Res. 80:244-251
Stamm, S., Zhu, J., Nakai, K., Stoilov, P., Stoss, O. and Zhang, M.Q. (2000)
An alternative exon database (AEDB) and its statistical analysis,
DNA and Cell Biol.,19:739-756
Hofmann, Y., Lorson, C.L., Stamm, S., Androphy, E.J. and Wirth, B. (2000)
Htra2-beta1 stimulates an exonic splicing enhancer and can restore full- length SMN expression to survival motor neuron 2 (SMN2),
Proc. Natl. Acad. Sci. USA 97:9618-9623
Hirsch, E., Oohashi, T., Ahmad, M., Stamm, S. and Fässler, R., (2000)
Peri-Implantation lethality in mice lacking the Sm motif-containing protein Lsm4,
Mol. Cell. Biol., 20:1055-1062
Gao, Q.-S., Memmott, J., Lafyatis, R., Stamm, S., Screaton, G. and Andreadis, A. (2000)
Complex regulation of tau exon 10, whose missplicing causes frontotemporal dementia.,
kjh., 74: 490-500
Meyer, T., Fromm, A., Münch, C., Schwalenstöcker, B., Fray, A.E., Ince, P.G., Stamm, S., Völkel, H., Ludolph, A.C., and Shaw, P.J., (1999)
The RNA of the glutamate transporter EAAT2 is variably spliced in amyotrophic lateral sclerosis and normal individuals.
J.Neurol. Sci., 170: 45-50
Hartmann, A.M., Nayler, O., Schwaiger, F.W., Obermeier, A. and Stamm, S., (1999)
The interaction and colocalisation of Sam68 with the splicing associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59fyn
Mol. Biol. Cell.,10: 3909-3926
Stoss, O., Stoilov, P., Hartmann, A.M., Nayler, O. and Stamm, S., (1999)
The in vivo minigene approach to analyze tissue-specific splicing,
Brain Res. Prot., 3:383-394
Nayler, O. and Stamm, S., (1999)
ScienceLabDatabase: A computer program to organise a molecular biology laboratory.
Biotechniques 26: 1186-1191
Stoss, O., Schwaiger, F.W., Cooper, T.A., and Stamm, S., (1999)
Alternative splicing determines the intracellular localization of the novel muscle-specific protein Nop30 and its interaction with the splicing factor SRp30c.
J. Biol. Chem.,274: 10951-10962.
Stamm, S., Casper, D., Hanson, V., and Helfman, D.M., (1999)
Regulation of the neuron-specific exon of clathrin light chain B.
Mol. Brain Res., 64: 108-118
Daoud, R., Berzaghi, M., Siedler, F., Hübener, M., and Stamm, S., (1999)
Activity dependent regulation of alternative splicing patterns in the rat brain.
Eur. J. Neurosci., 11: 788-802
Nayler, O., Schnorrer, F., Stamm, S., Ullrich, A., (1998)
The cellular localisation of the SR protein kinase mCLK2 is regulated by serine 141 autophosphorylation.
J. Biol. Chem., 273: 34341-34348
Nayler, O., Cap, C. and Stamm , S. (1998)
Human transformer-2-beta gene: Complete nucleotide sequence, chromosomal localisation and generation of a tissue specific isoform.
Genomics 53, p. 191-202
Nayler, O., Strätling, W., Bourquin, J.-P., Stagljar, I., Lindemann, L., Jasper, H., Hartmann, A.M., Fackelmeyer, F.O., Ullrich, A., and Stamm, S. (1998)
SAF-B couples transcription and pre-mRNA splicing to SAR/MAR elements.
Nucl. Acids Res., . 26: p. 3542-3549.
Hartmann, A.M. and Stamm, S. (1997)
Molecular cloning of a novel alternatively spliced nuclear protein.
Biochem. Biophys. Res. Com., 1353: p. 224-230.
Nayler, O., Stamm, S., and Ullrich, A. (1997)
Characterisation and comparison of four SR protein kinases.
Biochem. J., 326: p. 693-700.
Beil, B., Screaton, G. and Stamm, S. (1997)
Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologues of tra-2 generated by alternative splicing.
DNA 16: 679-690
Stamm, S. and Brosius, J. (1995) Solid Phase PCR. in PCR II - A practical Approach. Oxford University Press. 55-70.
Cáceres, J., Stamm, S., Helfman, D.M. and Krainer, A.R. (1994)
Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors.
Science 265: 1706-1709. Stamm, S., Zhang, M.Q., Marr, T.G. and Helfman, D.M. (1994)
A sequence compilation and
comparison of exons that are alternatively spliced in neurons.
Nucl. Acids Res. 22: 1515-1526.
Stamm, S., G. J. Mulligan, A. R. Krainer and D. M. Helfman. (1994)
Non-radioactive RNAs by immunoblotting
Nucl. Acids Res. 22, 252-253
Stamm, S., D. Casper, J.P. Lees-Miller and D.M. Helfman. (1993)
Brain-specific Tropomyosins TMBr-1 and TMBr-3 have distinct patterns of expression during development and in adult brain Proc.
Natl. Acad. Sci. USA 90: 9857-9861
Miller, M.W. , S. Beushausen, A. Vitek, S. Stamm, I. Kupfermann, J. Brosius, and K.R. Weiss. (1993)
The Myomodulin-related Neuropeptides: Characterization of a Gene Encoding a Family of Peptide Cotransmitters in Aplysia
J. Neurosci. 13, 3358-3367
Miller, M.W., S. Beushausen, E.C. Cropper, K. Eisinger, S. Stamm, F.S. Vilim, A. Vitek, A. Zajc, I. Kupfermann, J. Brosius, and K.R. Weiss. (1993)
The Buccalin-related Neuropeptides: Isolation and Characterization of an Aplysia cDNA Clone encoding a Family of Peptide Cotransmitters.
J. Neurosci. 13, 3346-3357
Stamm, S. , D. Casper, J. Dinsmore, C. A. Kaufmann, J. Brosius and D. M. Helfman. (1992)
Clathrin Light Chain B: Gene structure and neuron-specific splicing.
Nucl. Acids Res. 19, 5097 - 5103
Kelly, K.A., S. Stamm and C.A. Kozak. (1992)
Expression and Chromosomal Localization of the Murine Cystic Fibrosis Transmembrane Conductance Regulator,
Genomics 13, 381- 388
Stamm, S., Gillo, B. and Brosius, J. (1991)
Temperature Recording from Thermocyclers used for PCR
Biotechniques 10, 430- 435
Stamm, S. and J. Brosius (1991)
Sanchored PCR
Nucl. Acids Res. 19, 1350
Stamm, S. and F M. Longo (1989)
Direct Sequencing of PCR Products Using the Maxam- Gilbert Method
GATA 7 142 - 143